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INT-777（S-EMCA）是有效的 TGR5 激动剂，EC50 为 0.82 μM。 INT-777（S-EMCA）在大鼠蛛网膜下腔出血后通过 TGR3/cAMP/PKA 信号通路抑制 NLRP5-ASC 炎症小体介导的神经炎症。 INT-777（S-EMCA）是一种有效的选择性TGR5（跨膜G蛋白偶联受体5）激动剂，EC50 为 0.82 μM。 在动物模型中，INT-777通过激活TGR5，增加胆汁流量，减少胆汁酸的合成，从而减轻肝脏损伤。 View INT-777 Datasheet. INT-777 (S-EMCA) 是 TGR5 (GPCR19) 的有效选择性激动剂，对 TGR5、TGR5 (N76A) 和 TGR5 (Y89F) 的 EC50 分别为 0.18 μM、3.9 μM 和 1.45 μM。 Quality confirmed by NMR & HPLC. See customer reviews, validations & product citations.
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